Plants are already historically a source of analgesic alkaloids, While their pharmacological characterization is often limited. Amid these pure analgesic molecules, conolidine, present in the bark of the tropical flowering shrub Tabernaemontana divaricata We demonstrated that, in contrast to classical opioid receptors, ACKR3 won't result in classical G protein https://arthurieulb.activablog.com/30303174/everything-about-what-is-conolidine