Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals with the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have determined recurrent mutations in genes regulating tumor mobile-microenvironment interact... https://davidq777iaq7.wikinarration.com/user