Contraindicated (one)pentobarbital will reduce the level or impact of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is responsible for the development and elimination of cariprazine's active metabolites. pentobarbital will minimize the extent or effect of buprenorphine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution... https://arthurvoevk.onesmablog.com/nembutal-pentobarbital-options-74905825