BACKGROUND:The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b). Arf and p16(Ink4a)) and is frequently inactivated in a large number of human cancers. Mechanisms regulating INK4/ARF expression are not fully characterized. PRINCIPAL FINDINGS:Here we show that in young proliferating embryonic fibroblasts (MEFs) the Polycomb Repressive Complex 2 (PRC2) member EZH2 together... https://www.popularfilm.blog/