Monitor Closely (1)pentobarbital will decrease the level or effect of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor patients already on buprenorphine subdermal implant who require newly-initiated treatment with CYP3A4 inducer for signs and symptoms of withdrawal. If the quota of the concomitant CYP3A4 ... https://doctorbookmark.com/story20356326/5-fatti-facile-circa-pentobarbital-natrium-descritto